Our Trials

Endocrinology and Diabetes

For more information please contact:

Elizabeth Mulrooney - Clinical Trial's Endocrinology and Diabetes 
4th Floor Daly Wing
Ph: (03) 9231 4765

Chronic Kidney Disease

TRCA-303 (VALOR-CKD)

A Phase 3b, Randomized, Double-blind, Placebo-controlled Study to Evaluate the Efficacy and Safetu of TRC101 in Delaying Chronic Kidney Disease Progression in Subjects with Metabolic Acidosis

Recruitment on hold


Type 2 Diabetes & CKD

NovoNordisk NN9535-4321

FLOW - Effect of semaglutide versus placebo on the progression of renal impairement in subjects with type 2 diabetes and chronic kidney disease

Recruitment on hold 

 Type 1 Diabetes

Baker Heart and Diabetes - Nox 1 and 4 inhibition in type 1 diabetic kidney disease T1DGKT137831

A physician-initiated double-blind, randomised, placebo-controlled, phase 2 study evaluating the efficacy and safety of inhibition of NADPH Oxidase with the first-in-class Nox-1/4 inhibitor, GKT137831, in adults with type 1 diabetes and persistently elevated urinary albumin excertion

Recruitment on hold 

Haematology

To view the current recruiting trials at the Haematology Clinical Trial Unit please click here.

Neurosciences

For more information please contact:
Alan Lai
Study Coordinator
alan.lai@unimelb.edu.au

Epilepsy

A prospective study to assess the safety of a sub-scalp monitoring device for the recording of brain electrical activity associated with the occurrence of epileptic seizures

Open to recruitment

Neurosurgery

For more information please contact:
Emma Priest
Clinical Research Nurse
emma.priest@svha.org.au

Ph: (03) 9231 3551

Glioma Associated Seizures

Pegasus: Perampanel in glioma associated seizures – efficacy and safety: a pilot phase II randomised controlled trial

Open to recruitment

Oncology

For more information please contact:
oncologytrialcoordinators@svha.org.au

Breast Cancer

ANZ 1601/BIG 16-02

A randomised phase III trial of adjuvant radiation therapy versus observation following breast conserving surgery and endocrine therapy in patients with molecularly characterised luminal A early breast cancer

Recruitment one hold

TRIO033

(New Adjuvant Trials with LEE) Phase III clinical trial of ribociclib (LEE011) with endocrine therapy in the adjuvant treatment of HR +ve, HER2-ve early breast cancer

Recruitment on hold

RAD1901-308

Elacestrant Monotherapy Vs. Standard of Care For The Treatment Of Patients With ER+/Her2- Advanced Breast Cancer Following Cdk4/6 Inhibitor Therapy: A Phase 3 Randomized, Open-Label, Active-Controlled, Multicentre Trial

Recruitment on hold

Glioblastoma

A phase III trial of extended temozolomide in newly diagnosed glioblastoma (EX-TEM)

Recruitment on hold

Upper GI

 SOM vs DXA

A prospective pilot study of body composition assessment in gastric and oesophageal cancers at St Vincent's Hospital

Recruitment on hold

AG0407GR

A randomised phase II/III trial of preoperative chemoradiotherapy versus preoperative chemotherapy for resectable gastric cancer

Recruitment on hold

Lower GI (Colon)

ctDNA-08

Circulating Tumour DNA Analysis Informing Aadjuvant Chemotherapy in Stage III Colon Cancer: A Multicentre Phase II/III Randomised Controlled Study

Recruitment on hold

 Lower GI (Colorectal)

Shared chare of colorectal cancer survivors

Recruitment on hold

Lower GI (Rectal)

ctDNA-11

Circulating Tumour DNA Analysis Informing Adjuvant Chemotherapy in Locally Advanced Rectal Cancer: A Multicentre Randomised Study

Recruitment on hold

Non-Small Cell Lung Cancer (NSCLC)

 CTC 0209 / ALTG 16/009

A Phase 2 trial of durvalumab (MEDI4736) and tremelimumab with chemotherapy in metastatic EGFR mutant non-squamous non-small cell lung cancer (NSCLC) following progression on EGFR Tyrosine Kinase Inhibitors (TKIs) (ILLUMINATE)

Recruitment on hold

MS200647_0005

A phase II multicentre randomized, open label controlled study of M7824 in combination with chemoradiation followed by consolidation with M7824 in comparison with chemoradiation followed by consolidation with Durvalumab or M7824 in participants with unresectable Stage III NSCLC

Recruitment on hold

Pancreatic

ctDNA-09

Circulating tumour DNA analysis informing adjuvant chemotherapy in early stage Pancreatic cancer: A multi-centre randomised study (Dynamic-Pancreas) 

Recruitment on hold

2016.2

Pancreatic cancer: Understanding Routine Practice and Lifting End results (PURPLE) A Prospective Pancreatic Cancer clinical registry

Recruitment on hold 

8951-CL-5201

A Phase 2, Open-Label, Randomized Study to Assess the Antitumor Activity and Safety of Zolbetuximab (IMAB362) in Combination with Nab-Paclitaxel and Gemcitabine (Nab-P + GEM) as First Line Treatment in Subjects with Claudin 18.2 (CLDN18.2) Positive, Metastatic Pancreatic Adenocarcinoma

Recruitment on hold

Prostate

I3Y-MC-JPCM

A Phase 2, Randomised, Double-blind, Placebo-Controlled Study of Abiraterone Acetate Plus Pednisone with or without Abemaciclib in Patients with Metastatic Castration Resistant Prostate Cancer

Recruitment on hold

Esophageal

BGB-A317-306

A Randomized, Placebo-controlled, double-Blind Phase 3 Study to Evaluate the Efficacy and Safety of Tislelizumab (BGB-A317) in combination with chemotherapy a First-Line Treatment in Patients with Unresectable, Locally advanced recurrent or metastatic Esophageal Squamous Cell Carcinoma 

Recruitment on hold

 Cutaneous Squamous Cell Carcinoma (CSCC)

R2810-ONC-1788

A Randomised placebo-controlled double blind study of adjuvant cemiplimab versus placebo after surgery and radiation therapy in patients with high risk cutaneous squamous cell carcinoma

Recruitment on hold

Liver

 CA209-9DW

Bristol-Myers Squibb, A Randomized, Multi-center, Phase 3 Study of Nivolumab in Combination with Ipilimumab Compared to Sorafenib or Lenvatinib as First-Line Treatment in Participants with Advanced Hepatocellular Carcinoma

Recruitment on hold

Solid Tumors

42756493CAN2002

A Phase 2 Study of Erdafitinib in Subjects with Advanced Solid Tumors and FGFR Gene Alterations

Recruitment on hold

Multiple

DB-020-002 

Phase 1 Randomised, double-blind, placebo controlled, multicentre study to evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics or Repeated doses of DB-020 in patients receiving Cisplatin

Recruitment on hold

Palliative Care

For more information please contact:

Prof Jennifer Philip
jphilip@unimelb.edu.au

 

ANAM

A Study to Evaluate the Efficacy and Safety of Anamorelin HCl for the Treatment of Malignancy Associated Weight Loss and Anorexia in Adult Patients With Advanced Non-Small Cell Lung Cancer (NSCLC)

Recruitment on hold


Care Plus

The Enhance care study: multi-site implementation of early palliative care in routine practice to improve health outcomes

Recruitment on hold

CHOICE

A novel intervention trial towards improving care of seriously ill

Recruitment on hold

JUICE

Just in Case of Emergency in palliative care

Recruitment on hold

Lung Pro

Evaluating the symptoms and quality of life of advanced lung cancer patients in the Victorian Comprehensive Cancer Centre (VCCC) using patient reported outcome measures (PROMS) - A prospective, cross sectional study

Recruitment on hold

Melatonin

Randomised, double-blind, placebo-controlled phase III trial of oral melatonin for the prevention of delirium in hospital in people with advanced cancer

Recruitment on hold

Pearl

A randomised phase 3 trial of Palliative care Early in Advanced Lung Cancers

Recruitment on hold

StepCare

A Randomised Phase II Trial to Examine Feasibility of Standardised, Early Palliative Care (STEP Care) for Patients with Advanced Cancer and their Carers

Recruitment on hold